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Genetic polymorphism in the Ptch1 gene. (A) Partial gene sequence of Ptch1 from human, FVB, C57BL/6J and DBA2 mice. (B) Partial amino acid sequence of patched protein from human, FVB, C57BL/6J and DBA2 mice. The boxed residues indicate the A→C polymorphism (A) and resulting amino acid substitution (B) in the PTCH1 protein.
