Table 2.

Multivariable^† associations of risk factors for colorectal neoplasia and high levels of inflammatory cytokines, Diet and Health Study, 1998–2002

	OR (95% CI)
Risk factors	CRP (≥12013.1ng/ml)	IL-6 (≥0.3571pg/ml)	TNF-α (≥2.2358pg/ml)
Age (years)
50–64	1.39 (0.97–2.0)	1.6 (1.02–2.5)	1.16 (0.82–1.65)
≥ 65	1.62 (1.06–2.48)	2.17 (1.31–3.59)	1.94 (1.29–2.91)
Female sex	2.25 (1.67–3.04)	0.85 (0.61–1.19)	0.94 (0.71–1.25)
Regular use of NSAIDs	1.19 (0.88–1.62)	1.47 (1.03–2.12)	1.34 (1.0–1.81)
Smoking status
Current	2.05 (1.31–3.23)	2.59 (1.6–4.2)	1.23 (0.79–1.91)
Past	0.85 (0.61–1.2)	1.01 (0.67–1.51)	0.93 (0.67–1.29)
Obesity
BMI 25 – 29.9 (kg/m2)	1.94 (1.34–2.83)	1.85 (1.22–2.83)	1.46 (1.04–2.05)
Level 1 abdominal adiposity‡	1.75 (1.1–2.79)	1.93 (1.17–3.18)	1.44 (0.95–2.2)
Level 2 abdominal adiposity‡	2.1 (1.33–3.23)	1.71 (0.83–3.55)	1.46 (0.96–2.22)
BMI ≥ 30 (kg/m2)	5.36 (3.61–7.96)	2.47 (1.58–3.85)	1.91 (1.32–2.76)
Level 1 abdominal adiposity‡	3.54 (1.9–6.6)	1.74 (1.04–2.92)	1.63 (0.89–2.97)
Level 2 abdominal adiposity‡	6.26 (4.04–9.68)	2.81 (1.73–4.56)	2.03 (1.35–3.05)
Physical activity (MET-minutes/day)
2nd tertile*	0.74 (0.5–1.09)	0.71 (0.44–1.14)	0.69 (0.47–1.01)
3rd tertile*	0.65 (0.43–0.99)	1.09 (0.68–1.74)	0.73 (0.49–1.09)
Daily energy intake (kcal)
2nd tertile*	1.06 (0.72–1.56)	0.73 (0.45–1.17)	0.80 (0.55–1.16)
3rd tertile*	1.45 (0.97–2.16)	1.16 (0.74–1.81)	1.02 (0.7–1.49)
Total daily fat intake (g)
2nd tertile*	1.01 (0.68–1.5)	0.92 (0.57–1.48)	0.86 (0.58–1.25)
3rd tertile*	1.48 (1.0–2.19)	1.29 (0.82–2.04)	1.24 (0.85–1.81)

^†Adjusted for age (30–49, 50–64, ≥65 years) and sex

^‡Defined based on waist circumference. In women, <80 (cm) defined as normal, 80–87.9 as action level 1, and ≥ 88 as action level 2 abdominal obesity. In men, <94 defined as normal, 94–101.9 as action level 1, and ≥102 as action level 2 abdominal obesity.

^*Tertiles are based on the distribution among controls.