Table 3.
Crude and adjusted† odds ratios (OR) and 95% confidence intervals (CI) for associations between colorectal adenomas and plasma levels of inflammatory cytokines, Diet and Health Study, 1998–2002
| Cases | Controls | OR (95% CI) | Adj. † OR (95% CI) | |||
|---|---|---|---|---|---|---|
| No. | % | No. | % | |||
| CRP | ||||||
| <2916.03 | 71 | 30.34 | 204 | 33.28 | 1. | 1. |
| 2916.03–12013 | 75 | 32.05 | 204 | 33.28 | 1.06 (0.72–1.54) | 0.99 (0.66–1.50) |
| ≥12013.1 | 88 | 37.61 | 205 | 33.44 | 1.23 (0.85–1.78) | 1.45 (0.95–2.23) |
| IL-6 | ||||||
| 0 | 122 | 50.83 | 403 | 64.86 | 1. | 1. |
| <0.3571 | 54 | 22.5 | 110 | 17.49 | 1.64 (1.12–2.41) | 1.78 (1.18–2.68) |
| ≥0.3571 | 64 | 26.67 | 111 | 17.65 | 1.93 (1.33–2.79) | 1.84 (1.24–2.74) |
| TNF-α | ||||||
| <1.3877 | 53 | 22.36 | 209 | 33.28 | 1. | 1. |
| 1.3877–2.2357 | 89 | 37.55 | 209 | 33.28 | 1.68 (1.14–2.48) | 1.54 (1.02–2.33) |
| ≥2.2358 | 95 | 40.08 | 210 | 33.44 | 1.78 (1.21–2.63) | 1.65 (1.09–2.50) |
Adjusted for age (30–49, 50–54, 55–59, 60–65, 65–69, 70–74, ≥75 years), sex and obesity (BMI<25 kg/m2; BMI 25–29.9 kg/m2 and action level 1 abdominal adiposity; BMI 25–29.9 kg/m2 and action level 2 abdominal adiposity; BMI ≥30 kg/m2 and action level 1 abdominal adiposity; or BMI ≥30 kg/m2 and action level 2 abdominal adiposity)