Table 1.
DNA alterations in tumor tissue and normal colon mucosa adjacent from tumors in patients with colorectal carcinoma grouped according to survival and Dukes stage.
Dead vs Alive | Dead | Alive | Dead | Alive | Dukes A | Dukes B | Dukes C | Dukes D | |
---|---|---|---|---|---|---|---|---|---|
Sample | Tumor DNA vs Tumor DNA | Tumor DNA vs reference DNA | Colon DNA vs reference DNA | Tumor DNA vs reference DNA | |||||
Chrom | Altered BAC clones per chromosome (%)a | ||||||||
1 | - | 2 | - | - | - | - | - | 14 | - |
2 | - | - | - | ≤0.5 | - | - | - | 2 | - |
3 | - | ≤0.5 | - | ≤0.5 | - | - | 2 | - | - |
4 | - | ≤0.5 | 1 | 2 | 2 | 8 | 3 | - | 1 |
5 | - | - | 2 | 1 | - | - | - | ≤0.5 | - |
6 | - | - | - | 2 | - | - | 1 | 5 | 1 |
7 | ≤0.5 | 1 | 1 | 1 | - | 9.2 | - | 30 | 45 |
8 | 72 | 82 | ≤0.5 | 5 | 3 | 2 | 1 | 55 | 47 |
9 | 15 | - | 2 | 1 | ≤0.5 | 2 | 16 | 2 | 4 |
10 | - | ≤0.5 | 1 | 2 | - | 1 | 2 | 8 | 5 |
11 | - | - | - | ≤0.5 | - | - | - | 1 | 1 |
12 | - | ≤0.5 | 1 | ≤0.5 | 2 | - | - | 2 | - |
13 | 8 | 61 | 2 | ≤0.5 | 2 | 67 | 14 | 70 | 50 |
14 | ≤0.5 | - | - | 1 | - | - | 6 | 1 | 2 |
15 | - | ≤0.5 | - | ≤0.5 | 4 | - | 1 | 11 | 4 |
16 | - | ≤0.5 | 2 | - | 2 | 5 | - | 8 | 9 |
17 | - | - | 1 | 1 | 44 | 10 | - | 28 | 13 |
18 | - | 25 | 1 | 1 | - | 61 | 6 | 70 | 35 |
19 | - | 2 | 8 | 3 | 38 | 2 | 2 | 2 | 32 |
20 | - | 45 | 53 | 3 | 7 | 46 | 57 | 73 | 76 |
21 | - | 5 | - | 2 | 6 | 5 | 16 | 2 | 15 |
22 | 2 | - | 1 | 3 | 9 | - | 4 | 52 | 4 |
Genome wide alterations | 4.4 | 8.0 | 2.1 | 1.1 | 3.2 | 6.8 | 3.6 | 14.7 | 11.6 |
Number of altered BAC clones in percent per chromosome.