TABLE 1.
Characteristics of 1020 Study Participants With Stable Coronary Heart Disease
| Variable | Depressed (n = 223) | Not Depressed (n = 797) | p |
|---|---|---|---|
| Age (years), mean ± SD | 62 ± 11 | 68 ± 11 | <.001 |
| Male sex | 156 (70) | 680 (85) | <.001 |
| White race | 135 (61) | 478 (60) | .90 |
| Married | 70 (32) | 364 (46) | .001 |
| Medical history | |||
| Diabetes | 68 (30) | 197 (25) | .09 |
| Myocardial infarction | 110 (50) | 435 (55) | .18 |
| Congestive heart failure | 40 (18) | 137 (17) | .80 |
| Hypertension | 158 (71) | 563 (71) | .99 |
| Stroke | 33 (15) | 114 (14) | .84 |
| Revascularization | 111 (50) | 489 (62) | .002 |
| COPD or asthma | 44 (20) | 119 (15) | .08 |
| Current smoker | 64 (29) | 137 (17) | <.001 |
| Regular alcohol use | 67 (30) | 226 (29) | .64 |
| BMI (kg/m2), mean ± SD | 29 ± 5.6 | 28 ± 5 | .02 |
| Physically active | 119 (54) | 529 (67) | <.001 |
| Medication use | |||
| β blocker | 124 (56) | 466 (58) | .44 |
| Statin | 130 (58) | 524 (66) | .04 |
| Aspirin | 174 (78) | 616 (77) | .82 |
| Renin-angiotensin system inhibitor | 110 (49) | 411 (52) | .55 |
| Antidepressant | |||
| SSRI | 63 (28) | 34 (4) | <.001 |
| Tricyclic | 18 (8) | 26 (3) | .002 |
| Other antidepressant | 46 (21) | 33 (4) | <.001 |
| Laboratory tests | |||
| HDL cholesterol | 45 ± 15 | 46 ± 14 | .58 |
| LDL cholesterol | 107 ± 36 | 104 ± 33 | .23 |
| Log C-reactive protein | 0.75 ± 1.3 | 0.70 ± 1.3 | .65 |
| Log NT pro-B-type natriuretic peptide | 5 ± 1.2 | 5.3 ± 1.4 | <.001 |
| Creatinine clearance | 87.2 ± 30.3 | 79.5 ± 27.8 | <.001 |
| Cardiac function | |||
| Resting heart rate, mean ± SD | 68 ± 12 | 68 ± 12 | .41 |
| Systolic blood pressure, mean ± SD | 133 ± 22 | 133 ± 21 | .89 |
| Diastolic blood pressure, mean ± SD | 76 ± 12 | 74 ± 11 | .14 |
Data are presented as number (%) or mean +/−SD.
SD = standard deviation; COPD = chronic obstructive pulmonary disease; BMI = body mass index; SSRI = selective serotonin reuptake inhibitor; HDL = high-density lipoprotein; LDL = low-density lipoprotein.