Table 1.
Genes and loci implicated in familial atrial fibrillation
| Genes | |||||
|---|---|---|---|---|---|
| Chr | Gene name | Effect | Inheritance | Reference | |
| 11p15.5 | KCNQ1/KvLQT1 | Increases IKs, Expected to shorten APD | AD | 10,14 | |
| 21q22.1 | KCNE2/MiRP1 | Increases IKs | AD | 11 | |
| 17q23.1-24.2 | KCNJ2 | Increases IK1; Expected to shorten APD | AD | 12 | |
| 12p13 | KCNA5 | Loss of IKur; prolongs APD | AD | 13 | |
| 3p21 | SCN5A | Hyperpolarizing shift of resting membrane potential; Expected to prolong APD | AD | 15-17 | |
| 1p36-p35 | NPPA | Results in mutant atrial natriuretic peptide; associated with shortened APD | AD | 26 |
| Genetic Loci | Chr | Gene | Comments | Inheritance | Reference |
|---|---|---|---|---|---|
| 5p13 | Unknown | Associated with sudden death | AR | 24 | |
| 6q14-q16 | Unknown | Overlaps with locus for DCM | AD | 23 | |
| 10q22-q24 | Unknown | Overlaps with locus for DCM | AD | 22 | |
| 10p11-q21 | Unknown | AD | 25 |
Abbreviations: Chr, Chromosome; AD, autosomal dominant; AR, autosomal recessive; DCM, dilated cardiomyopathy.