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. 2008 Dec 16;82(2):296–302. doi: 10.1093/cvr/cvn349

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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org.

The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that the original authorship is properly and fully attributed; the Journal, Learned Society and Oxford University Press are attributed as the original place of publication with correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org.

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The nSMase inhibitor GW4869 reverses hypoxic pulmonary vasoconstriction in vivo. Recordings of systemic (left panel, in closed chest rats via a catheter in the carotid artery) and pulmonary (right panel, in open chest rats via a catheter advanced through the right ventricle into the main pulmonary artery) arterial pressure in anesthetized ventilated rats treated with DMSO (vehicle) (A) or 1 mg Kg⁻¹ of GW4869 (B) administered intraperitoneally. Rats were exposed to alveolar hypoxia (10% O₂) as indicated.