Table 1.
Basal and insulin-stimulated cardiac performance in isolated working hearts after 2 and 5 weeks of high-fat diet
| 2 Weeks | 5 Weeks | |||||||
|---|---|---|---|---|---|---|---|---|
| Basal NC, n = 10 | Basal HF, n = 8 | Ins NC, n = 11 | Ins HF, n = 7 | Basal NC, n = 8 | Basal HF, n = 8 | Ins NC, n = 10 | Ins HF, n = 10 | |
| Heart rate (b.p.m.) | 324.5 ± 7.3 | 299.3 ± 6.3** | 327.1 ± 6.9 | 309.6 ± 8.0 | 311.9 ± 7.7 | 312.3 ± 5.2 | 319.8 ± 6.0 | 289.7 ± 4.8*† |
| SP (mmHg) | 67.0 ± 1.0 | 70.2 ± 0.9* | 75.8 ± 0.6‡ | 75.0 ± 1.5‡ | 81.6 ± 1.1 | 76.7 ± 1.3** | 83.6 ± 1.0 | 82.5 ± 1.3‡ |
| DP (mmHg) | 40.4 ± 0.8 | 42.7 ± 1.2 | 40.8 ± 0.8 | 43.3 ± 1.1 | 52.4 ± 1.8 | 49.0 ± 1.4 | 45.3 ± 1.2‡ | 44.8 ± 1.3† |
| DevP (mmHg) | 26.6 ± 0.7 | 27.5 ± 0.8 | 35.0 ± 0.6‡ | 31.7 ± 0.9**‡ | 29.2 ± 1.1 | 27.7 ± 0.7 | 38.3 ± 0.9‡ | 37.7 ± 0.6‡ |
| Coronary flow (mL/min) | 4.0 ± 0.1 | 3.8 ± 0.2 | 4.1 ± 0.1 | 3.8 ± 0.1 | 4.0 ± 0.1 | 3.8 ± 0.1 | 3.6 ± 0.1† | 4.0 ± 0.1** |
| Aortic flow (mL/min) | 9.5 ± 0.2 | 9.3 ± 0.2 | 9.9 ± 0.3 | 9.0 ± 0.2* | 10.1 ± 0.2 | 10.3 ± 0.2 | 10.7 ± 0.3 | 10.3 ± 0.2 |
| Cardiac output (mL/min) | 13.6 ± 0.3 | 13.2 ± 0.3 | 14.0 ± 0.3 | 12.9 ± 0.3** | 14.1 ± 0.2 | 14.1 ± 0.2 | 14.3 ± 0.3 | 14.3 ± 0.2 |
| Cardiac power (mW/g) | 30.2 ± 1.1 | 27.7 ± 0.9 | 40.1 ± 1.5‡ | 31.8 ± 1.7**# | 31.8 ± 2.3 | 28.0 ± 0.8 | 38.2 ± 1.5‡ | 40.7 ± 1.5‡ |
Ins, 1 nM insulin stimulation. NC, normal chow; HF, high fat; SP, systolic pressure; DP, diastolic pressure; DevP, developed pressure (SP minus DP). Cardiac output = coronary flow + aortic flow; cardiac power is derived from cardiac output and DevP, normalized to heart weight.
*P < 0.05 and **P < 0.01 vs. normal chow under similar heart perfusion conditions. †P < 0.05 and ‡P < 0.01 vs. no insulin, under similar dietary conditions. #P = 0.07 vs. no insulin under similar dietary conditions.