. Author manuscript; available in PMC: 2009 Oct 23.

Published in final edited form as: J Med Chem. 2008 Sep 27;51(20):6334–6347. doi: 10.1021/jm800389v

Table 6.

Opioid agonist functional activities in [³⁵S]GTPγS binding assays

No	hDOR^a			rMOR^a

	LogEC₅₀^b	EC₅₀ (nM)	Emax (%)^c	LogEC₅₀^b	EC₅₀ (nM)	Emax (%)^c
1^d	−8.5 ± 0.21	2.9	48	−7.5 ± 0.09	32	46
2	−8.1 ± 0.11	8.6	58	−8.2 ± 0.17	7.0	55
3	−8.6 ± 0.13	2.6	52	−7.7 ± 0.18	21	47
Biphalin	−9.0 ± 0.17	1.1	83
DPDPE	−8.8 ± 0.25	1.6	69
DAMGO				−7.4 ± 0.19	37	150

Expressed from HN9.10 cell.

The log EC₅₀ ± standard error are logarithmic values determined from the non-linear regression analysis of data collected from 2 independent experiments performed in duplicate (4 independent experimental values per drug concentration)

Net total bound/basal binding ×100.

See a reference.³⁸