Table 1.

Comparison of model structure and accuracy with respect to experimental observations for wild-type and mutant phenotypes.

	Bagheri et al. (2008)	Kuczenski et al. (2007)	Leise & Moin (2007)	Leloup & Goldbeter (1998)	Ruoff et al. (2005)	Smolen et al. (2004)	Ueda et al. (2001)	Xie & Kulasiri (2007)
Structure
Mirrored PER and TIM	No	Yes	Yes	Yes	Yes	Yes	Yes	Yes
Includes phosphorylation	Yes	Yes	No	Yes	No	Yes	No	No
Includes compartmentalization	Yes	Yes	Yes	Yes	Yes	Yes	Yes	No
Wild type
Free-running τ (h)	23.24	23.8	23.9	24.1	21.2	24	24	24
mRNA to protein phase (h)	3	3.5	7	2	n/a	5	3.8	n/a
CLK to PEr phase (h)	11	4	6	n/a	7	2	8	11
VRI to PBP phase (h)	3	2	n/a	n/a	6.5	3	n/a	6
PRC
Maximum phase advance (h)	1	—	3.5	3	—	2	0.3–3.2 a	2
Maximum phase delay (h)	0.6	—	3.5	4.5	—	4	0.3-2.2 a	4
Duration of dead zone (h)	9	—	6	12	—	10	8	6
Mutant
per overexpression	Short τ	Short τ	—	—	Short τ	Short τ	—	—
vri underexpression	Short τ	—	—	—	Short τ	Short τ	—	—
vri over- & pdp underexpression	Long τ	—	—	—	—	Long τ	—	—
Low PDP levels	Nominal	—	—	—	—	—	—	—
High PDP levels	Nominal	—	—	—	—	—	—	—
Consecutive PDP	Nominal	—	—	—	—	Nominal	—	—
CLK-jrk	Arrythmic	Arrythmic	—	—	—	Arrythmic	Arrythmic	Arrythmic
per 01 or tim 0	Nominal	Arrythmic	Arrythmic	—	—	Arrythmic	Arrythmic	Arrythmic

NOTE: The circadian behavior corresponding to several Drosophila melanogaster models is outlined. Each row outlines a circadian quality relating to the structure of the model, or wild-type and mutant phenotype behavior. Each column reflects dynamics specific to a published model. The boldface data reflect experimentally accurate attributes. The empty cells denote data not addressed in the development of the model.

^aThe maximum phase advance/delay specific to the Ueda et al. (2001) model depends on the magnitude of the light input as it varies between the 2- and 10-fold for the duration of 1 h.