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. 2009 Feb 12;23(5):610–619. doi: 10.1210/me.2008-0455

Figure 6.

Figure 6

Roles for the MLL3/4-SET-INI1 interactions in the cross talk between ASCOM and Swi/Snf. A, Schematic representation of wild-type and a deletion mutant of MLL3 expressed in MLL3Δ/Δ MEF cell line (10). Wild-type and MLL3Δ/Δ MEF cell lines were subjected to ChIP analyses for the recruitment of MLL3 proteins to RAR-β2. Before ChIP, cells were treated with 0.1 μm RA for 15 min. B, Schematic representation of INI1 deletion and alanine scanning mutants. The yeast two-hybrid results with the INI1 deletion mutants fused to B42 and LexA-MLL3/4591-4904 are as indicated. C, The alanine scanning mutants in full-length INI1 fused to B42 were tested for interactions with LexA-MLL3/4591-4904 and LexA-hBRM/321-693 in yeast, as determined by liquid β-galactosidase assays. B42 alone and B42-INI1 wild type were used as controls.