Table 2.

Aromatic amino acid transporters

MTS, type	SLC (HUGO)	Name	Mechanism*	Preferred substrates	References	***
B0+	SLC6A14	ATB0,+	s[AA][2Na+Cl–]	KRASCTNQHMILVFYW	Sloan and Mager, 1999	Sl
B0	SLC6A19	B0AT1	s[AA][Na+]	ASCTQFWY	Broer et al., 2004	Sl
B0 like		DmNAT1	s[AA][Na+]	KRASCTNQHMILVFYW	Miller et al., 2008	Sl
B0 like		AgNAT8	s[AA][2Na+/K+]	FY(l-DOPA)	Meleshkevitch et al., 2006
B0 like		AgNAT6	s[AA][2/1Na+/K+]	WY(5-HTP)	This study
L	SLC7A5	LAT1	e[AA]:[AA]**	ASCTQFWY	Mastroberardino et al., 1998	Sl
y+	SLC7A8	LAT2	e[AA]:[AA]**	QHMLIVFYW	Broer et al., 2000	sl, bl
b0+	SLC7A9	b0,+AT	e[AA+]:[AA0]	KRASCTNQHMILVFYWC	Rajan et al., 1999	sl
b0+	SLC7A15	arpAT	e[AA+]:[AA0]	KRASCTNQHMILVFYWC	Fernandez et al., 2005	sl
T	SLC16A10	TAT	u (passive flux)	FYW (low affinity)	Kim et al., 2001	bl, pf

^*Mechanism abbreviations are: s, symporter, e, obligatory exchanger; u, uniporter or facilitated flux mechanism

^**Tertiary active uptake transporter for amino acids exchanged for intracellular amino acids, which were accumulated, for instance, via a metabolic pathway or Na⁺-coupled symporter

^***Factors which limit or make impossible a contribution of the specified transporter in the accumulation of aromatic amino acids. Specific constrains are abbreviated as: sl, selectivity; bl, basolateral location in absorptive epithelia; pf, passive flux; la, insufficiently low affinity. Other abbreviations: AA, amino acid; MTS, mammalian transport system; SLC, solute carrier family; ref, representative references