TABLE 1.
Summary for ubiquitination of S5a by E2/E3 pairs tested in this study
“Yes” indicates that rapid ubiquitination of S5a was observed. “No” indicates that little or no ubiquitination of S5a was observed.
E3 type
|
E3
|
E2 type
|
Class I
|
Class II
|
Hetero-dimeric E2
|
||
---|---|---|---|---|---|---|---|
E2 | UbcH5 | Ubc4 | UbcH7 | UbcH1 | UbcH13/Uev1a | ||
U-box | CHIP | Yes | No | ||||
Monomeric Ring | MuRF1 | Yes | No | No | |||
Siah2 | Yes | ||||||
Mdm2 | Yes | ||||||
Parkin | Yes | ||||||
Oligomeric Ring | SCFβTRCP1 | Yes | |||||
APC | Yes | ||||||
HECT | E6AP | Yes | |||||
Nedd4 | Yes | Yes |