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Model of the nucleotide excision repair damage sensor. A, modeled UvrA·UvrB complex based on superposition of the corresponding domains onto the experimentally determined structure. Note that the proposed DNA-binding path on UvrA (5) and the DNA-binding site on UvrB (Protein Data Bank code 2FDC (25)) are aligned (pink). B, the models for lesion recognition by the UvrA·UvrB complex.
