FIGURE 3.
Overlay of SR-3737, SR-3451, and p38 with compound 14e. A, JNK3 (green) and p38 (blue) superimposed in schematic ribbon format (only the SR-3737 JNK3 is shown). Ligands for SR-3737 (magenta), SR-3451 (cyan), and compound 14e (orange) (32) are shown in stick format. B, close-up of the ATP binding pocket showing the overlapping ligands with the highlighted JNK3 amino acids from Fig. 1 in stick format. C, close-up of the ATP binding pocket showing the overlap of SR-3737 and compound 14e with the highlighted JNK3 amino acids from Fig. 1 in stick format. D, close-up of the ATP binding pocket showing the overlap of SR-3451 and compound14e with the highlighted JNK3 amino acids from Fig. 1 in stick format. The figure was generated by using PyMOL.