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. 2009 May 8;284(19):12874–12885. doi: 10.1074/jbc.M809633200

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Copyright © 2009, The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 5. — Mice expressing intermediate CD45 levels survive B. anthracis infection. A, mice with intermediate CD45 expression levels (62%) challenged with Ames B. anthracis spores showed a 65% survival rate. In contrast, CD45^100%, CD45^0%, CD45^11%, CD45^36%, or CSV10^+/- (62%) mice with inactive CD45 phosphatase activity showed little to no protection after B. anthracis challenge. B, immunohistochemical staining of spleen with anti-capsule antibody did not show any bacterial load in the CD45^62% mice surviving B. anthracis challenge (∼48 h) (right panel) versus moribund CD45^100% mice (48 h) (left panel). Scale bar = 100 μm, 20× magnification. RP, red pulp; MZ, marginal zone; PALS, periarteriolar lymphoid sheath.