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Screening for PS1 mutants active without NCT
| Mutants | No. of positive clones |
|---|---|
| Screening (3.7 × 105 cells tested) from PS1 F411Y mutant | |
| F411Y/S438P (the original mutant) | 40 |
| V236M/F428Y/F411Y | 1 |
| Screening (3.7 × 105 cells tested) from PS1 S438P mutant | |
| M84K/S438P | 1 |
| Y115F/S438P | 2 |
| L173V/S438P | 1 |
| L232H/S438P | 2 |
| L232F/S438P | 1 |
| V236A/S438P | 4 |
| V236M/S438P | 13 |
| L241I/S438P | 1 |
| A246T/S438P | 8 |
| V252M/S438P | 1 |
| D403G/S438P | 2 |
| F411Y/S438P (the original mutant) | 3 |
| I416F/S438P | 1 |
| F441L/S438P | 7 |
