Table 2.
Genotype distributions of polymorphisms related (allele frequency, P < 0.05) to chronic kidney disease (CKD) as determined by the chi-square test
| Gene symbol | Polymorphism | dbSNP | CKD | Controls | P (genotype) | P (allele frequency) | FDR |
|---|---|---|---|---|---|---|---|
| APOE | –219G→T | rs405509 | – | – | 0.0106 | 0.0028 | 0.0463 |
| GG | – | 51 (6.5) | 398 (9.0) | – | – | – | |
| GT | – | 419 (53.9) | 1876 (42.3) | – | – | – | |
| TT | – | 308 (39.6) | 2164 (48.7) | – | – | – | |
| MMP1 | –519A→G | rs1144393 | – | – | 0.0100 | 0.0043 | 0.0463 |
| AA | – | 602 (77.5) | 3612 (81.4) | – | – | – | |
| AG | – | 163 (21.0) | 788 (17.8) | – | – | – | |
| GG | – | 12 (1.5) | 35 (0.8) | – | – | – | |
| HMOX1 | –413T→A | rs2071746 | 0.0166 | 0.0048 | 0.0463 | ||
| TT | – | 199 (25.6) | 1351 (30.4) | – | – | – | |
| TA | – | 381 (49.0) | 2085 (47.0) | – | – | – | |
| AA | – | 198 (25.4) | 1002 (22.6) | – | – | – | |
| UCP2 | –866G→A | rs659366 | 0.0201 | 0.0060 | 0.0463 | ||
| GG | – | 187 (24.0) | 1219 (27.5) | – | – | – | |
| GA | – | 384 (49.4) | 2221 (50.0) | – | – | – | |
| AA | – | 207 (26.6) | 998 (22.5) | – | – | – | |
| MMP1 | –1607/1G→2G | rs1799750 | 0.0133 | 0.0074 | 0.0463 | ||
| 1G1G | – | 94 (12.1) | 482 (10.9) | – | – | – | |
| 1G2G | – | 368 (47.3) | 1901 (42.8) | – | – | – | |
| 2G2G | – | 316 (40.6) | 2055 (46.3) | – | – | – | |
| GNB3 | 1429C→T | rs5446 | – | – | 0.0264 | 0.0087 | 0.0463 |
| CC | – | 538 (69.2) | 2886 (65.1) | – | – | – | |
| CT | – | 219 (28.1) | 1352 (30.5) | – | – | – | |
| TT | – | 21 (2.7) | 193 (4.4) | – | – | – | |
| MMP3 | A→G (Lys45Glu) | rs679620 | – | – | 0.0193 | 0.0091 | 0.0463 |
| AA | – | 99 (12.7) | 431 (9.7) | – | – | – | |
| AG | – | 343 (44.1) | 1927 (43.4) | – | – | – | |
| GG | – | 336 (43.2) | 2079 (46.9) | – | – | – | |
| AGTR1 | G→A (Ala163Thr) | rs12721226 | – | – | 0.0092 | 0.0093 | 0.0463 |
| GG | – | 773 (99.4) | 4430 (99.8) | – | – | – | |
| GA | – | 5 (0.6) | 7 (0.2) | – | – | – | |
| AA | – | 0 (0) | 0 (0) | – | – | – | |
| PECAM1 | G→A (Gly670Arg) | rs1131012 | – | – | 0.0355 | 0.0114 | 0.0498 |
| GG | – | 190 (24.4) | 919 (20.7) | – | – | – | |
| GA | – | 383 (49.2) | 2206 (49.7) | – | – | – | |
| AA | – | 205 (26.4) | 1312 (29.6) | – | – | – | |
| UCP3 | –55C→T | rs1800849 | – | – | 0.0238 | 0.0125 | 0.0498 |
| CC | – | 360 (46.3) | 2208 (49.8) | – | – | – | |
| CT | – | 329 (42.3) | 1847 (41.6) | – | – | – | |
| TT | – | 89 (11.4) | 383 (8.6) | – | – | – | |
| MMP3 | –1171/5A→6A | rs3025058 | – | – | 0.0796 | 0.0254 | 0.0925 |
| 5A5A | – | 21 (2.7) | 97 (2.2) | – | – | – | |
| 5A6A | – | 218 (28.0) | 1095 (24.7) | – | – | – | |
| 6A6A | – | 539 (69.3) | 3245 (73.1) | – | – | – | |
| PECAM1 | 1454C→G (Leu125Val) | rs668 | – | – | 0.0810 | 0.0303 | 0.0940 |
| CC | – | 166 (21.3) | 1102 (24.8) | – | – | – | |
| CG | – | 396 (50.9) | 2213 (49.9) | – | – | – | |
| GG | – | 216 (27.8) | 1123 (25.3) | – | – | – | |
| TNF | –850C→T | rs1799724 | 0.10619 | 0.0317 | 0.0940 | ||
| CC | – | 528 (67.9) | 3174 (71.5) | – | – | – | |
| CT | – | 221 (28.4) | 1129 (25.5) | – | – | – | |
| TT | – | 29 (3.7) | 135 (3.0) | – | – | – | |
| CPB2 | G→A (Ala147Thr) | rs37742264 | – | – | 0.0993 | 0.0329 | 0.0940 |
| GG | – | 453 (58.2) | 2428 (54.7) | – | – | – | |
| GA | – | 282 (36.3) | 1693 (38.2) | – | – | – | |
| AA | – | 43 (5.5) | 317 (7.1) | – | – | – | |
| HMOX1 | G→C (Asp7His) | rs2071747 | – | – | 0.0498 | 0.0404 | 0.1077 |
| GG | – | 676 (86.9) | 3711 (83.6) | – | – | – | |
| GC | – | 94 (12.1) | 686 (15.5) | – | – | – | |
| CC | – | 8 (1.0) | 40 (0.9) | – | – | – | |
| PTGS1 | C→T | rs883484 | – | – | 0.1118 | 0.0476 | 0.1123 |
| CC | – | 275 (35.4) | 1688 (38.1) | – | – | – | |
| CT | – | 2116 (47.7) | 2116 (47.7) | – | – | – | |
| TT | – | 131 (16.9) | 631 (14.2) | – | – | – | |
| ABCA1 | 2583A→G (Ile823Met) | rs4149313 | – | – | 0.1408 | 0.0477 | 0.1123 |
| AA | – | 117 (15.0) | 593 (13.4) | – | – | – | |
| AG | – | 365 (46.9) | 1998 (45.0) | – | – | – | |
| GG | – | 296 (38.1) | 1846 (41.6) | – | – | – |