Table 4.
Comparison of various normalized urinary marker levels in patients with AKI and non-AKIa
| Pre-OP | Immediately Post-OP | 3 h Post-OP | 18 h Post-OP | 24 h Post-OP | |
|---|---|---|---|---|---|
| Normalized KIM-1 (ng/mg Ucr)b | |||||
| AKI | 1.1 (0.7 to 1.4) (n = 36) | 1.4 (0.1 to 2.4)c (n = 35) | 0.7 (0.0 to 2.1)d (n = 28) | 2.6 (1.2 to 4.0) (n = 34) | 2.1 (1.4 to 3.9) (n = 34) |
| early AKI | 1.3 (0.8 to 1.7)d (n = 16) | 2.5 (0.2 to 4.5)cf (n = 15) | 1.5 (0.0 to 3.6)d (n = 12) | 4.3 (1.1 to 8.2)d (n = 15) | 4.2 (1.5 to 10.2)de (n = 15) |
| late AKI | 0.8 (0.5 to 1.4) (n = 20) | 0.5 (0.0 to 2.0) (n = 20) | 0.4 (0.0 to 1.5) (n = 16) | 2.5 (1.1 to 3.3) (n = 19) | 1.6 (1.1 to 2.2) (n = 19) |
| non-AKI | 0.8 (0.6 to 1.0) (n = 54) | 0.0 (0.0 to 0.6) (n = 54) | 0.0 (0.0 to 0.3) (n = 51) | 1.7 (1.3 to 2.7) (n = 48) | 1.7 (1.0 to 2.7) (n = 42) |
| Normalized NAG (U/gram Ucr) | |||||
| AKI | 4.7 (2.7 to 9.6) (n = 36) | 47.9 (28.5 to 93.9) (n = 35) | 19.8 (6.1 to 27.9) (n = 28) | 6.4 (5.3 to 9.2)d (n = 34) | 7.6 (4.4 to 13.9) (n = 34) |
| early AKI | 7.6 (1.0 to 16.3) (n = 16) | 37.8 (18.0 to 132.3) (n = 15) | 20.9 (3.7 to 43.6) (n = 12) | 7.7 (5.1 to 12.5) (n = 15) | 7.3 (3.6 to 22.5) (n = 15) |
| late AKI | 4.3 (2.4 to 9.6) (n = 20) | 51.9 (26.2 to 168.8) (n = 20) | 17.7 (5.3 to 97.8) (n = 16) | 5.6 (5.2 to 10.7) (n = 19) | 8.0 (3.5 to 13.9) (n = 19) |
| non-AKI | 4.2 (2.1 to 5.6) (n = 54) | 24.9 (14.5 to 55.6) (n = 54) | 9.2 (5.5 to 16.5) (n = 51) | 4.0 (3.2 to 7.2) (n = 48) | 7.5 (4.7 to 10.2) (n = 42) |
| Normalized NGAL (ng/mg Ucr) | |||||
| AKI | 6.1 (2.8 to 12.0) (n = 36) | 4579.0 (1544.8 to 8074.2) (n = 35) | 2071.4 (455.4 to 6211.0)d (n = 28) | 71.2 (31.7 to 255.6)c (n = 34) | 69.6 (9.9 to 323.1) (n = 34) |
| early AKI | 9.5 (1.4 to 85.1) (n = 16) | 2044.1 (36.0 to 7247.3) (n = 15) | 1153.3 (1.1 to 8000.0) (n = 12) | 70.8 (6.4 to 1418.2)d (n = 15) | 73.3 (8.0 to 4752.1) (n = 13) |
| late AKI | 5.4 (2.4 to 13.1) (n = 20) | 7151.1 (1704.2 to 9810.8)d (n = 20) | 3041.7 (324.5 to 7457.0)d (n = 16) | 75.6 (26.5 to 251.9)d (n = 19) | 70.1 (9.1 to 621.6) (n = 19) |
| non-AKI | 3.8 (2.9 to 6.7) (n = 54) | 2308.5 (344.1 to 5044.8) (n = 54) | 130.6 (35.9 to 601.9) (n = 51) | 15.8 (9.0 to 22.0) (n = 48) | 20.9 (13.8 to 31.6) (n = 42) |
| Delta Scr (%) | |||||
| AKI | −10.00 (−10.00 to 0.00)d (n = 34) | −20.00 (10.00 to 31.45)c (n = 36) | |||
| early AKI | 0.00 (−20.00 to 7.60)d (n = 14) | 40.00 (30.00 to 70.00)c (n = 16) | |||
| late AKI | −10.00 (−20.00 to 0.00) (n = 20) | 5.00 (−10.00 to 15.50)d (n = 20) | |||
| non-AKI | −20.00 (−20.00 to −10.00) (n = 54) | −10.00 (−20.00 to 0.00) (n = 54) | |||
a
Values are medians (95% confidence interval for median).
b
Ucr, urine creatinine concentration.
c
P < 0.005 versus non-AKI.
d
P < 0.05 versus non-AKI.
e
P < 0.005 versus late AKI.
f
P < 0.05 versus late AKI.