Table 4.
Pathologic findings on kidney specimens in 13 adult patients with CFa
| Patient | Light Microscopy
|
Immunofluorescence | Diagnosis | ||
|---|---|---|---|---|---|
| Glomeruli (Sclerotic Glomeruli) | Tubules/Interstitium | Vessels | |||
| 1 | Endocapillary proliferation, mesangial neutrophils infiltration | – | – | Glomerular C3 deposits, humps | Postinfectious GN |
| 2 | FSGS | ci2/ct2 calcium oxalate crystals | ah0/cv0 | Negative | FSGS |
| 3 | KW (6/17) | ci2/ct2 | ah2/cv1 | Linear IgA, IgG, and albumin deposits | Diabetic glomerulopathy |
| 4 | KW (1/17) | ci1/ct1 | ah3/cv1 | Linear IgA, IgG, and albumin deposits | Diabetic glomerulopathy |
| 5 | Mesangial and subepithelial amyloid deposits (7/20) | ci2/ct2 amyloid deposits | ah2/cv2 amyloid deposits | AA amyloidosis | Diffuse amyloidosis AA subtype |
| 6 | Normal (1/3) | ci1/ct1 | ah0/cv0 | Negative | MCD/CTIN |
| 7 | Diffuse mesangial proliferation (0/18) | ci1/ct0 | ah0/cv1 | Mesangial IgA deposits | IgAN |
| 8 | Normal (0/16) | i0/t0 | ah0/cv1 | Subepithelial IgG deposits | MN |
| 9 | Mesangial amyloid deposits (2/14) | i0/t0 intratubular vacuoles | Arteriolar amyloidosis | AA amyloidosis | Diffuse amyloidosis AA subtype |
| 10 | FSGS (1/14) | ci1/ct0 | ah1/cv0 | Negative | FSGS |
| 11 | KW (0/10) | ci1/ct1 | ah0/cv1 | Linear IgA, IgG, and albumin deposits | Diabetic glomerulopathy |
| 12 | Normal (2/21) | ci2/ct2 | ah0/cv0 cellular infiltrate, intratubular pigments | Negative | CTIN |
| 13 | Mesangial and subepithelial amyloidosis (4/23) | ci2/ct2 amyloidosis | Amyloidosis ah2/cv1 | AA amyloidosis | Diffuse amyloidosis AA subtype |
a
ah, arteriolar hyaline thickening; ci, interstitial fibrosis; ct, tubular atrophy; cv, vacular fibrous intimal thickening.