Figure 7.

Effects of intravenous injection of microvesicles (MVs) or mesenchymal stem cells (MSCs) into acute kidney injury (AKI) mice. Mice were given intramuscular injection of 8 ml/kg of 50% glycerol on day 0, followed by intravenous injection of MVs or RNase-treated MVs or MSCs or vehicle as control on day 3. (A and B) Creatinine and blood urea nitrogen values at the beginning of the experiments and on day 3, 5, 8, and 15 after glycerol administration. ANOVA with Dunnet's multicomparison test: *P < 0.05 MV- or MSC- treated AKI mice versus control AKI mice. (C) Representative micrographs of renal histology at day 5 and 8 after glycerol administration in control AKI mice, in AKI mice injected with 15 μg of MVs or RNase-MV or with 75,000 MSCs. Magnification: ×400.