Table 1.
Incidence and severity of CIA in control and experimental animals
| Experiment | Strain | CII | CIA (%)* | Age of Onset, weeks | Mean age of onset† | Arthritic index‡ | Histology index§ |
|---|---|---|---|---|---|---|---|
| 1 | SWR/j | + | 0/6 (0) | − | − | 0 | 0 |
| 1 | DBA/1j | − | 0/10 (0) | − | − | 0 | 0 |
| 2 | DBA/1j | − | 0/10 (0) | − | − | 0 | 0 |
| 1 | DBA/1j | + | 10/10 (100) | 5 | 8.0 ± 0.8 | 20.4 ± 4.4 | 20.5 ± 4.6 |
| 2 | DBA/1j | + | 10/10 (100) | 5 | 7.0 ± 0.5 | 25.6 ± 3.7 | 24.5 ± 5.7 |
| 1 | (DBA/1j × SWR/j)F1 | + | 14/19 (73.7) | 6 | 9.5 ± 0.7 | 15.8 ± 2.1 | N.D. |
| 1 | (DBA/1j × SWR/j)F2 | + | 55/87 (63.2) | 5 | 8.1 ± 0.4 | 17.9 ± 1.4 | 12.8 ± 1.8 |
| 2 | (DBA/1j × SWR/j)F2 | + | 51/80 (63.8) | 5 | 8.0 ± 0.4 | 11.4 ± 1.4 | 13.2 ± 2.3 |
| Totals | |||||||
| DBA/1j | 20/20 (100) | 5 | 7.5 ± 0.5 | 23.0 ± 2.9 | 22.5 ± 3.7 | ||
| F2 Exp. | (DBA/1j × SWR/j)F2 | 106/167 (63.5) | 5 | 8.1 ± 0.3 | 14.8 ± 1.0 | 13.0 ± 1.5 |
N.D., Not done.
*
Number of arthritic animals/total number immunized.
†
Weeks after immunization ± S.E.M.
‡
Arthritic and histology index ± S.E.M.