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. 2009 Apr 9;10:10. doi: 10.1186/1471-2091-10-10

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Copyright © 2009 Karetsou et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Mapping on the SET/TAF-Iβ structure of the central region essential for H3 binding. Views of the central region of SET/TAF-Iβ found to be essential for H3 binding in this work (blue), the homologous domain (named subdomain C) of yeast NAP-1 (green) and the homologous domain of yeast Vps75 (red). PDB codes used are 2E50 for human SET/TAF-Iβ, 2AYU for yeast NAP-1 and 2ZD7 for yeast Vps75. The central β-sheet is a common structural motif found in all histone chaperones known todate. Molecular images were generated with PyMol [61].