Table 3.
Physiologic parameters of the study rats.
| FHF without CSF drainage (n = 19) |
FHF with CSF drainage (n = 14) |
|
|---|---|---|
| MAP (mmHg) | 122 ± 5 (4) | 118 ± 5 (4) |
| Serum glucose (mg/dl) | 157 ± 30 (10) | 128 ± 26 (10) |
| CSF volume (μl) | None | 351 ± 119 (12) |
| ICP (mmHg) | 6.2 ± 0.8 (18) | 9.95 ± 2.15 (6)** |
**
Ventriculostomy was placed 5 days prior to FHF induction. Among the 33 FHF rats that progressed into comatose stages, 19 received CSF drainage via syringe aspiration, and 14 did not. There was no difference in MAP and serum glucose between the two study groups. The initial ICP readings showed a trend of higher readings in the CSF drainage group (P = 0.053). The numbers in parentheses indicate the number of animals in which the measurement was made.
FHF, fulminant hepatic failure; CSF, cerebrospinal fluid; MAP, mean arterial pressure; ICP, intracranial pressure.