Table 2.
Patient No. | Gender | Age (year) | Histology | Stage | Gene transfer access | rAd-p53 |
BAI times | Local response | TTP (month) | Survival duration (month) | |
Time | Dose (×1012 VP) | ||||||||||
1 | M | 40 | Adeno | IIIa | TA | 2 | 2 | 3 | SD | 9 | 12 |
2 | M | 56 | Squam | IIIb | TA | 2 | 1 | 2 | SD | 6 | 8 |
3 | M | 39 | Adeno | IIIa | PI | 3 | 2 | 3 | PD | 1 | 2 |
4 | M | 51 | Large cell | IIIb | PI | 2 | 2 | 2 | PR | 10 | 12 |
5 | M | 53 | Squam | IIIa | PI/TA | 4 | 3 | 4 | CR | 13 | 12 |
6 | M | 71 | Adeno | IV | PI & TC | 2 | 2 | 1 | SD | 5 | 9 |
7 | M | 80 | Adeno | IV | PI | 2 | 1 | 2 | SD | 6 | 7 |
8 | M | 48 | Adeno | IIIb | PI & LN | 2 | 3 | 3 | PR | 7 | 12 |
9 | F | 56 | Squam | IV | TA | 2 | 4 | 4 | SD | 4 | 7 |
10 | F | 72 | Large cell | IV | PI | 3 | 3 | 2 | PD | 2 | 3 |
11 | M | 74 | Squam | IV | PI | 1 | 1 | 2 | SD | 5 | 6 |
12 | M | 61 | Adeno Squam | IIIb | PI | 4 | 1 | 2 | PR | 7 | 11 |
13 | F | 54 | Adeno | IIIa | TA | 2 | 3 | 3 | PR | 9 | 12 |
14 | F | 53 | Adeno | IV | TA | 3 | 2 | 3 | PR | 6 | 8 |
15 | M | 54 | Squam | IIIb | TA | 4 | 2 | 2 | CR | 13 | 12 |
16 | M | 59 | Squam | IIIa | PI | 4 | 2 | 2 | PR | 11 | 12 |
17 | M | 79 | Squam | IV | TA | 2 | 1 | 2 | PR | 7 | 12 |
18 | M | 46 | Squam | IIIa | TA | 3 | 2 | 3 | PR | 8 | 12 |
19 | M | 68 | Squam | IIIa | TA | 2 | 2 | 1 | PR | 10 | 12 |
M: male; F: female; Adeno: adenocarcinoma; Squam: squamous; TA: transarterial infusion; TC: thoracic cavity; PI: percutaneous injection; LN: lymph nodes; BAI: bronchial arterial infusion; SD: stable disease; PD: progressive disease; PR: partial response; CR: complete response; TTP: time to progression