Figure 7. Summary of the adaptive response.
Results and hypotheses regarding transcriptional regulators and functional categories identified in this study are summarized. The influence of hydrogen peroxide is determined by its concentration within the cell. In addition to treatment dose, several cellular processes affect the level of H2O2. In order to enter the cell, hydrogen peroxide must first diffuse across the plasma membrane. Inside the cell, peroxide levels are reduced by degradation into oxygen and water. Squares denote the expression of genes or gene sets (rectangles) following each of the three treatment protocols (pretreatment, adapted, and acute). Conversely, circles denote the sensitivity of the corresponding gene deletion for a particular protein or protein set (oval) in the adapted and acute treatment protocol. Arrows between different objects indicate either an activating (triangular arrowhead) or inhibitory (flat arrowhead) influence. The figure number(s) which provides support for each link are shown in brackets. A red “X” denotes a hypothesis which is refuted by experimental observation.