Figure 1. The α-actinin structure.

A) α-actinin is a dimer with three major domains: an actin binding domain, a calmodulin homology domain, and a central rod domain. The monomers are arranged in an anti-parallel manner. B) VMD [52] generated image of the α-actinin dimer rod domain. Each of the four spectrin repeats are colored according to conformation. R1 is colored in red, R2 in yellow, R3 in green, and R4 in blue. In dimer conformation R1 is interacting with R4 and R2 is interacting with R3.