Table 3. Correlations of (a) plasma total DNA, (b) serum methylated DNA, (c) CTC and (d) molecular markers.
|
Response
|
|||
|---|---|---|---|
| (a) Total DNA levels | Stable (n=27) | Progressive (n=46) | P-value |
| High | 16 | 39 | 0.01 |
| Low | 11 | 7 | |
| (b) Methylated serum DNA | Stable (n=26) | Progressive (n=46) | |
| Methylated | 10 | 31 | 0.02 |
| Unmethylated | 16 | 15 | |
| (c) CTC | Stable (n=26) | Progressive (n=46) | |
| Positive | 5 | 22 | 0.02 |
| Negative | 21 | 24 | |
| (d) Molecular markers | Stable (n=25) | Progressive (n=46) | |
| Negative | 6 | 4 | 0.01 |
| At least one marker positive | 10 | 8 | |
| Two or more markers positive | 7 | 18 | |
| Three markers positive | 2 | 16 | |
CTC=circulating tumour cell.