Table 3. Allelic imbalance (AI) in 14 microsatellite markers at 2p22.1–p16.1 in lung tumours of asbestos-exposed and non-exposed patients.
|
AI/n (%)a
|
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Microsatellite markers within the chromosomal region
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| 2p22.1 | 2p21 | 2p16.3 | 2p16.2 | 2p16.1 | |||||||||||
| Exposure | Asbestos fibre countb | D2S2328 | D2S2259 | D2S119 | D2S2298 | D2S2174 | D2S2240 | D2S2378 | D2S2182 | D2S391 | D2S2739 | D2S123 | D2S2251 | D2S2153 | D2S378 |
| Asbestos-exposed n=13 | 33.4 (5.9–145.0) | 2/11 (18) | 5/9 (56) | 5/10 (50) | 4/10 (40) | 3/5 (60) | 5/10 (50) | 7/8 (88) | 1/3 (33) | 4/7 (57) | 8/11 (73) | 5/8 (63) | 4/7 (57) | 3/8 (38) | 4/9 (44) |
| Non- exposed n=14 | 0.06 (0.0–0.5) | 1/8 (13) | 3/7 (43) | 1/8 (13) | 3/9 (33) | 3/7 (43) | 4/10 (40) | 4/10 (40) | 3/6 (50) | 3/7 (43) | 3/9 (33) | 0/5 (0) | 2/9 (22) | 3/8 (38) | 1/10 (10) |
| P c | 1.00 | 1.00 | 0.15 | 1.00 | 1.00 | 1.00 | 0.07 | 1.00 | 1.00 | 0.17 | 0.08 | 0.30 | 1.00 | 0.14 | |
a
Number of cases with AI/informative cases.
b
Million g−1 dry lung; mean (range).
c
P (Fisher's exact test); bold if the corresponding marker is presented in Figure 3.