Table 3. Levels of N7-meG (fmol μg−1 DNA) in DNA extracted from PBMC samples from patients in the treatment groups indicated and as described in the Patients and Methods section.
| Sampling time | LM/TMZ | TMZ alone | LM/TMZ at progression | Protracted LM/TMZ |
|---|---|---|---|---|
| Pre-dose | ||||
| N | 22 | 20 | 5 | 7 |
| Mean | 0.02 | 0.19 | 3.56 | 0.33 |
| Range | 0–0.5 | 0–3.0 | 1.5–6.1 | 0–0.5 |
| Day 5 | ||||
| N | 1 | 5 | 1 | — |
| Mean | 38.0 | 52.9 | 51.0 | — |
| Range | — | 41.6–80.1 | — | — |
| Day 6 | ||||
| N | 12 | 8 | 1 | — |
| Mean | 43.7 | 55.9 | 49.4 | — |
| Range | 29.7–64.2 | 34.1–79.3 | — | — |
| Day 7 | ||||
| N | 10 | 5 | 3 | — |
| Mean | 35.9 | 43.6 | 35.3 | — |
| Range | 18.4–55.5 | 34.7–52.6 | 20.9–51.3 | — |
| Day 8 | ||||
| N | 3 | 4 | 1 | — |
| Mean | 24.3 | 42.8 | 34.4 | — |
| Range | 17.7–29.2 | 28.3–64.7 | — | — |
| Day 10 | ||||
| N | — | — | — | 3 |
| Mean | — | — | — | 16.1 |
| Range | — | — | — | 13.1–18.0 |
| Day 14 | ||||
| N | — | — | — | 4 |
| Mean | — | — | — | 6.9 |
| Range | — | — | — | 3.6–13.9 |
Abbreviations: LM=lomeguatrib; TMZ=temozolomide.