Table 2.
Risk of Preterm Delivery and SGA in Women With Elevated cFN
| Preterm Delivery (<37 wk) | SGA (<10th Centile) | Preterm and SGA | |||||||
|---|---|---|---|---|---|---|---|---|---|
| % | Crude OR | Adjusted ORa (95% CI) | % | Crude OR | Adjusted ORa (95% CI) | % | Crude OR | Adjusted ORa (95% CI) | |
| Model 1 | |||||||||
| Normotensive (n = 436) | 7.5 | 1.0 | 1.0 | 7.5 | 1.0 | 1.0 | — | — | — |
| Normotensive and elevated cFN (n = 169) | 6.5 | 0.6 (0.3-1.4) | 0.7 (0.3-1.5) | 9.2 | 1.2 (0.6-2.3) | 1.3 (0.7-2.5) | — | — | — |
| Model 2 | |||||||||
| Transient hypertension (n = 119) | 9.2 | 1.0 | 1.0 | 9.0 | 1.0 | 1.0 | 2.5 | 1.0 | 1.0 |
| Transient hypertension and elevated cFN (n = 52) | 13.5 | 1.6 (0.6-4.3) | 0.9 (0.3-2.8) | 17.7 | 1.2 (0.5-3.2) | 1.2 (0.4-3.6) | 5.8 | 1.6 (0.5-4.8) | 1.1 (0.3-3.8) |
| Model 3 | |||||||||
| Preeclampsia (n = 79) | 27.9 | 1.0 | 1.0 | 14.3 | 1.0 | 1.0 | 7.6 | 1.0 | 1.0 |
| Preeclampsia and elevated cFN (n = 108) | 46.3 | 2.1 (1.2-3.5) | 1.8 (0.9-3.6) | 26.4 | 2.1 (1.1-4.1) | 2.1 (0.9-4.6) | 18.5 | 3.1 (1.3-7.5) | 3.0 (1.0-8.7) |
| Model 4 | |||||||||
| Preeclampsia and hyperuricemia (n = 42) | 42.9 | 1.0 | 1.0 | 16.7 | 1.0 | 1.0 | 9.5 | 1.0 | 1.0 |
| Preeclampsia, hyperuricemia, and elevated cFN (n = 79) | 58.2 | 1.5 (0.8-3.0) | 2.0 (0.9-4.3) | 30.4 | 2.5 (1.1-6.0) | 2.9 (1.0-8.0) | 24.1 | 3.2 (1.2-9.0) | 4.2 (1.2-14.8) |
Abbreviations: cFN, cellular fibronectin; CI, confidence interval; OR, odds ratio; SGA, small for gestational age.
a
Adjusted for prepregnancy body mass index and smoking; models 1, 2, and 3 were additionally adjusted for hyperuricemia.