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Clinical plasma pharmacokinetics. Plasma samples were collected from patients receiving PPX as a 10- to 30-minute infusion once every 3 weeks. Conjugated and unconjugated paclitaxel were measured by validated HPLC/MS methods. The plasma concentration of conjugated paclitaxel declines biphasically and is characterized by a prolonged distribution phase and an elimination phase with a long terminal half-life.
