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Simulation of the polymeric coating (EudraGI tract® S-100) of Asacol® (a) enlarged section of the interface between the drug core and coating at t = 0 h; (b) after 2 h in the stomach fluid at pH = 1.2; (c) after 1 h in the intestinal fluid I (proximal) at pH = 6.8; (d) after 15 min in the intestinal fluid II (distal) at pH = 7.2; (e) Coating thickness dissolution in pH 1.2, 6.8 and 7.2 gastrointestinal buffers.
