Figure 6.

Histological analysis of hematoxylin-eosin stained lung tissue 24 hrs after treatment (original magnification 100X); (A) In saline-treated animals (n = 2), the lung tissue was almost entirely normal, as shown in this view; (B) The con A-treated rats (n = 2) demonstrated extensive pneumonic changes in their lungs. A bronchiole and adjacent alveoli show mixed inflammatory cell infiltrates including neutrophils and lymphocytes, accompanied by alveolar hemorrhage; (C) In liposome-treated animals (n = 2), patchy lymphocytic infiltrates were noted around a bronchiole, blood vessels, and in the interstitium in the left upper lobe of one of the rats receiving the liposomes; (D) In AVT-treated animals (n = 2), alveolar material is focally visible (see arrows) in the lungs, and may represent remnants of the particles (original magnification 100X).