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. Author manuscript; available in PMC: 2009 May 4.
Published in final edited form as: Biochim Biophys Acta. 2007 Feb 22;1773(6):784–793. doi: 10.1016/j.bbamcr.2007.02.004

Fig 6.

Fig 6

Transient Inter-Compartmental Contact Sites (TICCS) mediate lipid traffic between membrane compartments and lipid filled adiposomes. Here depicted is the movement of a lipid cargo such as membrane sterol (yellow) between the cell surface and lipid droplets using endosomal intermediates. Migration of the sterol is bidirectional and depends on the formation endosome-endosome as well as endosome-droplet TICCS. Recognition sites (red) for each compartment contain the molecular machinery necessary for the formation of TICCS. Compartmental specificity of TICCS formation is regulated by Rab-GTP.