. Author manuscript; available in PMC: 2010 Apr 15.

Published in final edited form as: J Am Chem Soc. 2009 Apr 15;131(14):5054–5055. doi: 10.1021/ja900827p

Table 2.

Ruthenium catalyzed transfer hydrogenative coupling sulfonamido-allene 1e to aldehydes 2a-2l^a


*Coupling to Aryl Aldehydes*
91% Yield, 3a	70% Yield, 3b^b	77% yield, 3c
94% yield, 3d	74% Yield, 3e	90% Yield, 3f

*Coupling to Enals*
61% Yield, 3g^b	63% Yield, 3h^b	65% Yield, 3i^b

*Coupling to Aliphatic Aldehydes*
77% Yied, 3j	85% Yield, 3k	69% Yield, 3l

In all cases, cited yields are of isolated material and represent the average of two runs. In each case, >20:1 anti-diastereoselectivity is observed, as determined by ¹H NMR analysis. See Supporting Information for detailed experimental procedures.

Two equivalents of allene 1e were used.