Figure 2.

Brain and liver of Swiss Webster mice. (a) Panoramic view of non-infected control mouse brain with a clean large vessel. Haematoxylin–eosin, 200×. (b) Infected mouse, large haemorrhage in cerebellum, Purkinje cell area. Haematoxylin–eosin, 400×. (c) Infected mouse, brain vessel full of pigment-containing monocytes. Parasitized and non-parasitized RBC can be observed adherent to activated monocytes. Haematoxylin–eosin, 500×. (d) Panoramic view of a normal mouse liver, showing typical architecture, clean sinusoids and resting Kupffer cells. Haematoxylin–eosin, 200×. (e) Infected mouse, moriform vacuolization of hepatocytes and pigmented Kupffer cells. Haematoxylin–eosin, 200×. (f) Detail of moriform vacuolization, hypertrophic Kupffer cells containing malarial pigment and intra-sinusoidal clusters of mononuclear cells. Haematoxylin–eosin, 400×.