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Brain region specific nature of β-catenin KO. Sagittal section of an 8 week old reporter mouse brain showing LacZ expression (blue) following Cre recombination in ROSA26 mice mated with Cre expressing mice. Note the high expression in cortex and hippocampus (A). Audioradiographs visualizing the in situ hybridization of β-catenin in 12 week old wild type and knock out animals at the level of (from top to bottom) the striatum, dorsal hippocampus, and cerebellum (B).
