Table 1.
Demographic and Clinical Characteristics of Unmedicated Subjects With RMDD and Healthy Controls
| Characteristic | RMDD Subjects (n=15) | Controls (n=13) |
|---|---|---|
| Sex, No. F/M | 14/1 | 12/1 |
| Age, mean (SD), y | 39 (11) | 39 (12) |
| Age at onset, mean (SD), y | 24 (8.3) | NA |
| Major depressive episodes, mean (SD), No. | 2.7 (1.4) | 0 |
| Time in remission, mo | ||
| Mean (SD) | 46 (45) | NA |
| Range | 8-240 | NA |
| Antidepressant drug–naive, No. | 2 | 13 |
| Previous use of NRIs and TCAs, No. | 4 | 0 |
| Time medication free, mo | ||
| Mean (SD) | 35 (28) | NA |
| Range | 7-118 | NA |
| First-degree relative(s) with mood disorder, No. | 14 | 0 |
| Remote (> 1 y ago) history of alcohol abuse, No. | 3 | 1 |
| History of drug abuse, No. | 0 | 0 |
| Montgomery-Asberg Depression Rating Scale score at study entry, mean (SD) | 2.3 (2.1) | 0.5 (1.2) |
Abbreviations: NA, not applicable; NRIs, norepinephrine reuptake inhibitors; RMDD, major depressive disorder in remission; TCAs, tricyclic antidepressants.