Table 6.

Regions Where Catecholamine Depletion–Induced Changes in Metabolism Correlated Positively With Corresponding Changes in Mood, Anxiety, and Anhedonic Symptoms in Subjects With RMDD and Controls^a

Brain Regions	Coordinates, x/y/z	t Value
Montgomery-Asberg Depression Rating Scale
Ventromedial PFC	−4/54/−8	6.01a
L superior temporal gyrus	−59/−26/14	5.12
L posterior insula	−42/−10/−1	4.92
R inferior parietal lobe	62/−39/28	4.78
R middle temporal gyrus	53/−62/1	4.72
Medial parietal cortexb	−2/−68/33	4.60
	14/−63/57	4.57
R ventrolateral PFC	42/44/18	4.55
L superior parietal lobe	−28/−60/47	4.05
Beck Anxiety Inventory
Medial cerebellum	−8/−71/−13	4.87
R medial parietal cortexb	10/−63/57	4.66
L fusiform gyrus	−46/−67/−13	4.36
R medial thalamus	6/−23/9	3.85
R superior temporal gyrus	61/−2/7	3.75
Anterior cingulate cortex	−2/21/27	3.65
Posterior hypothalamus	2/−14/−4	3.42
R parahippocampal gyrus	32/−17/−19	3.35
Snaith-Hamilton Pleasure Scale (Negative Correlation)
R precentral gyrus	32/−14/65	5.24
R dorsolateral PFC	36/8/47	4.11
Medial parietal cortexb	−12/−61/56	4.93
	4/−70/46	4.54
	2/−32/53	3.81
Midcingulate gyrus	4/−8/41	4.35
L medial orbital gyrus/accumbens area	−14/17/−9	4.18
L thalamus	−18/−25/12	4.08
L superior temporal gyrus	−59/−42/19	3.91
	−63/−36/15	3.68
R middle temporal gyrus	53/−64/7	3.77
R inferior parietal lobule	48/−36/48	3.77
	62/−42/24	3.65
R superior temporal gyrus	53/−13/10	3.72
R accumbens area	14/10/−4	3.71
L posterior cingulate cortex	−12/−39/35	3.64

Abbreviations: L, left; PFC, prefrontal cortex; R, right; RMDD, major depressive disorder in remission.

^aInterpretation of stereotaxic coordinates is as in Table 4. Increases in symptoms were calculated for each session (maximum score minus baseline score). The behavioral score for each subject was calculated as the difference in symptom increase between drug condition and placebo condition, reflecting the magnitude of catecholamine depletion–induced symptoms. The statistical models for assessing changes in normalized regional cerebral metabolic rates for glucose included the main effect of drug vs placebo, the main effect of the behavioral score (results shown in the table), and the main effect of subject. Results shown in the table were significant at P_uncorrected<.001. No region was identified where the changes in metabolism correlated negatively with the changes in Montgomery-Asberg Depression Rating Scale scores or positively with the changes in Snaith-Hamilton Pleasure Scale scores at this significance threshold. In 1 region (the left temporal polar cortex; −42, 6, −32; t = 4.40), the metabolic changes correlated negatively with corresponding changes in Beck Anxiety Inventory scores at P_uncorrected<.001.

^bPrecuneus.