Table 1.
Baseline characteristics of study participants by thirds of the adipokine distributions*
| Resistin | Adiponectin | |||||||
|---|---|---|---|---|---|---|---|---|
| Range Third | 1.2–10.9 (ng/ml) | 11.0–14.9 (ng/ml) | 15.0–110.0 (ng/ml) | 0.7–6.4 (ug/ml) | 6.5–11.0 (ug/ml) | 11.1–59.9 (ug/ml) | ||
| 1 | 2 | 3 | P value | 1 | 2 | 3 | P value | |
| N | 904 | 923 | 912 | 920 | 900 | 919 | ||
| Female (%) | 54 | 53 | 53 | 0.9 | 29 | 52 | 79 | <0.0001 |
| Age (yr) | 60 (9) | 61 (9) | 63 (10) | <0.0001 | 60 (10) | 61 (9) | 62 (9) | <0.0001 |
| Systolic blood pressure (mm Hg) | 126 (19) | 126 (19) | 130 (19) | <0.0001 | 128 (17) | 127 (19) | 126 (20) | 0.09 |
| Treatment with antihypertensive medications (%) | 26 | 32 | 42 | <0.0001 | 38 | 34 | 28 | <0.0001 |
| Type 2 Diabetes (%) | 8.1 | 10.0 | 15.0 | <0.0001 | 17.7 | 11.8 | 3.6 | <0.0001 |
| Current cigarette smoking (%) | 13 | 12 | 15 | 0.3 | 15 | 13 | 12 | 0.4 |
| Serum total/high-density lipoprotein cholesterol ratio | 3.8 (1.2) | 4.1 (1.4) | 4.2 (1.3) | <0.0001 | 4.7 (1.4) | 4.1 (1.1) | 3.3 (1.0) | <0.0001 |
| Baseline prevalent coronary heart disease (%) | 8.3 | 6.9 | 10.1 | 0.05 | 12.1 | 8.2 | 5.0 | <0.0001 |
| Valvular heart disease (%) | 1.8 | 2.3 | 3.6 | 0.05 | 2.1 | 2.5 | 3.1 | 0.4 |
| Electrocardiographic left ventricular hypertrophy (mm) | 12.2 (5.1) | 12.5 (5.3) | 12.9 (5.0) | 0.04 | 13.7 (5.1) | 12.5 (5.0) | 11.4 (5.2) | <0.0001 |
| Body mass index | 27 (5) | 28 (5) | 29 (6) | <0.0001 | 30 (5) | 29 (5) | 26 (5) | <0.0001 |
| Waist circumference (cm) | 97 (13) | 100 (14) | 103 (14) | <0.0001 | 105 (13) | 101 (13) | 94 (14) | <0.0001 |
| Insulin resistance with the homeostasis model† | 3.2 (1.9) | 3.6 (2.0) | 4.0 (1.9) | <0.0001 | 5.0 (1.9) | 3.6 (1.8) | 2.6 (1.7) | <0.0001 |
| C-reactive protein† (mg/ml) | 2.8 (3.2) | 4.0 (5.2) | 6.1 (12.1) | <0.0001 | 4.5 (6.3) | 4.9 (10.9) | 3.6 (5.8) | 0.004 |
| Plasma B-type natriuretic peptide† (pg/ml) | 13 (17) | 15 (18) | 17 (23) | 0.0004 | 13 (19) | 15 (21) | 18 (19) | <0.0001 |
| Estimated glomerular filtration rate (ml/min/1.73m2) | 89 (18) | 85 (18) | 80 (21) | <0.0001 | 85 (18) | 85 (20) | 84 (20) | 0.2 |
| Urine albumin/creatinine ratio† (mg/g) | 5.0 (5.1) | 5.6 (4.9) | 6.8 (5.5) | 0.002 | 4.6 (5.4) | 5.7 (5.4) | 7.3 (4.5) | <0.0001 |
| Adiponectin† (ug/ml) | 8.9 (1.9) | 8.4 (1.9) | 8.0 (1.3) | 0.0008 | x | x | x | x |
| Resistin† (ng/ml) | x | x | x | x | 13.6 (1.5) | 13.1 (1.5) | 12.4 (1.5) | <0.0001 |
*
P values indicate significance for trend across strata of resistin. Standard deviations are in parenthesis.
†
Antilogarithm