Table 1.
Parameters for plasma glucose levels and relative pharmacological bioavailability Data represents the mean ± SD, n = 6 per group
| Insulin subcutaneous | Insulin-loaded SLN | Oral insulin solution | |
|---|---|---|---|
| Insulin dose (IU/kg) | 2.5 | 50.0 | 50.0 |
| Cmin (%) | 48.6 ± 3.9 | 73.2 ± 7.7 | 80.8 ± 8.3 |
| Tmin (h) | 2 | 14 | 6 |
| AAC | 478 ± 125 | 484 ± 196 | 260 ± 37 |
| PA%a | - | 5.1 ± 3.1* | 1.6 ± 0.7 |
Cmin, minimum plasma glucose concentration (% of initial); Tmin, time to Cmin; AAC, area above the plasma glucose levels time curves; PA%, relative pharmacological bioavailability.
a
Based on AAC for subcutaneous administration (SC).
*
Statistically significant differences from oral insulin solution control (p < 0.05).