FIGURE 7.
Viral clearance in vacv-immunized WT and gld mice. WT or gld BALB/c mice were immunized with 3×106 PFU of either vacvβ-gal or vacvG and at least 3 weeks later challenged i.n. with 3×106 PFU of RSV. Lungs were harvested at either day 4 or 7 post-RSV challenge, homogenized, and subsequently snap frozen in liquid nitrogen until analysis by plaque assay on Vero cells. Pooled data from 3 individual experiments with an n= 3–4 mice per group in each individual experiment is shown. Error bars represent the standard error of the mean. *, significantly different than any vacvβ-gal-immunized mice (p<0.05). #, significantly different than WT vacvG-immunized mice (p<0.05). $, significantly different than WT vacvβ-gal-immunized mice (p<0.05) as determined by ANOVA.