Table 2.
Pearson correlation coefficients for various RBP4 measurements and other parameters as indicated in patients with and without gestational diabetes mellitus
| RBP4 EIA |
RBP4 western blot |
RBP4:transthyretina |
RBP4:retinolb |
|||||
|---|---|---|---|---|---|---|---|---|
| GDM (n=42) | No GDM (n=45) | GDM (n=41) | No GDM (n=45) | GDM (n=41) | No GDM (n=45) | GDM (n=41) | No GDM (n=45) | |
| Retinol | 0.09 (0.575) | 0.33 (0.034) | 0.48 (0.002) | 0.11 (0.495) | 0.10 (0.534) | 0.10 (0.516) | −0.65 (<0.001) | −0.87 (<0.001) |
| Age | 0.01 (0.959) | 0.24 (0.112) | −0.22 (0.170) | 0.15 (0.341) | 0.02 (0.879) | −0.05 (0.720) | −0.19 (0.244) | 0.01 (0.983) |
| BMI pre- pregnancyc | 0.13 (0.404) | −0.11 (0.477) | 0.10 (0.557) | 0.05 (0.732) | 0.28 (0.082) | 0.28 (0.067) | 0.13 (0.422) | −0.21 (0.189) |
| BMI pregnancyc | 0.14 (0.362) | −0.03 (0.847) | 0.19 (0.232) | 0.10 (0.517) | 0.27 (0.088) | 0.36 (0.017) | 0.06 (0.422) | −0.25 (0.110) |
| Systolic BP | 0.33 (0.042) | 0.32 (0.034) | 0.34 (0.039) | 0.21 (0.178) | 0.41 (0.010) | 0.18 (0.249) | 0.08 (0.626) | −0.06 (0.704) |
| Diastolic BP | 0.25 (0.116) | 0.13 (0.399) | 0.29 (0.068) | 0.30 (0.046) | 0.21 (0.199) | 0.19 (0.210) | 0.05 (0.782) | −0.04 (0.801) |
| Fasting insulin | 0.15 (0.358) | 0.11 (0.475) | 0.14 (0.39) | 0.28 (0.069) | 0.14 (0.387) | 0.42 (0.004) | −0.01 (0.989) | −0.02 (0.891) |
| 1 h insulin | 0.18 (0.335) | 0.05 (0.756) | 0.30 (0.096) | −0.07 (0.649) | 0.25 (0.165) | −0.02 (0.895) | −0.09 (0.641) | −0.17 (0.314) |
| 2 h insulin | −0.01 (0.998) | 0.14 (0.377) | −0.01 (0.928) | 0.21 (0.193) | −0.02 (0.928) | 0.31 (0.047) | −0.39 (0.028) | 0.03 (0.853) |
| HOMA-IR | 0.19 (0.230) | 0.10 (0.518) | 0.15 (0.354) | 0.28 (0.061) | 0.22 (0.169) | 0.39 (0.008) | 0.07 (0.671) | 0.01 (0.975) |
| Fasting glucose | 0.27 (0.083) | 0.03 (0.863) | 0.13 (0.409) | 0.16 (0.287) | 0.14 (0.387) | 0.01 (0.950) | 0.34 (0.031) | 0.08 (0.636) |
| 1 h glucose | 0.08 (0.610) | −0.04 (0.807) | 0.08 (0.636) | −0.03 (0.826) | −0.13 (0.414) | −0.12 (0.439) | 0.28 (0.075) | −0.15 (0.339) |
| 2 h glucose | 0.16 (0.310) | −0.01 (0.945) | −0.19 (0.243) | 0.28 (0.070) | −0.30 (0.059) | 0.21 (0.164) | −0.07 (0.671) | 0.06 (0.693) |
| Triacylglycerol | 0.25 (0.114) | 0.06 (0.690) | −0.03 (0.840) | 0.35 (0.024) | −0.05 (0.758) | 0.23 (0.149) | −0.10 (0.534) | 0.08 (0.620) |
| GFR | 0.02 (0.920) | −0.22 (0.154) | 0.03 (0.839) | −0.07 (0.640) | −0.09 (0.594) | −0.07 (0.662) | 0.26 (0.103) | 0.16 (0.337) |
| HbA1c | 0.24 (0.125) | 0.05 (0.763) | −0.10 (0.545) | 0.23 (0.137) | 0.23 (0.149) | 0.26 (0.091) | 0.25 (0.121) | 0.25 (0.125) |
Values are Pearson correlation coefficients (p value)
All data were collected after an overnight fast at median week 29 in both participant groups; skewed variables were log-transformed
Molar ratio, according to the amounts of RBP4 and transthyretin determined by western blotting, calculated using a molecular mass of 21 kDa for RBP4 and 54 kDa for transthyretin as a homotetramer (n=19)
Molar ratio, according to the amount of RBP4 determined by western blotting and the amount of retinol determined by HPLC, calculated using a molecular mass of 21 kDa for RBP4 and 0.286 kDa for retinol (n=19)
Pre-pregnancy BMI was compared with RBP4 values obtained at median week 29 of pregnancy