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. Author manuscript; available in PMC: 2009 May 4.
Published in final edited form as: Prog Biophys Mol Biol. 2008 Mar 5;97(2-3):543–561. doi: 10.1016/j.pbiomolbio.2008.02.024

Table 5.

Comparison between canine LBBB animal model and LBBB patients

LBBB patients LBBB dogs
QRS duration LBBB 169±16ms 123±4ms
Controls 80−100ms 69±3ms
Inter-ventricular asynchrony (RV–LV pressure difference) LBBB −50±17ms −32±7ms
Controls −5±10ms −6±9ms
Intra-ventricular asynchrony (Electrical mapping, ms) LBBB 61±15ms 26±6ms
Controls NA 5±2ms
Time to first peak systolic shortening septum to LV lateral wall delay (MR tagging) LBBB 351±92ms 173±21ms
Controls NA −27±15ms
Septal to posterior wall motion delay (SPWMD) LBBB 192±92ms 221±13ms
Controls NA 64±9ms
Echocardiography (% of controls)
    Hypertrophy 142 (%) 117 (%)±15 (%)
    LV EDV/wall mass ratio 114 (%) 110 (%)±12 (%)
    Sep/lat wall mass ratio 98 (%)−90 (%) 84±2%
Myocardial blood flow (% of mean LV) Using PET Using microspheres
    Septum 93% 83±16%
    Lateral wall 113% 118±12%

Data derived from Verbeek et al. (2003), Verbeek et al. (2006), Zwanenburg et al. (2004), Vassallo et al. (1984), Pitzalis et al. (2002), Prinzen et al. (1995), Vernooy et al. (2005), Lindner et al. (2005).