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Age-related differences in frontal white matter NAA/Cr, mI/Cr, Glx/Cr, and Cho/Cr ratios in RTT subjects and healthy controls. NAA/Cr decreased with age and mI increased in age in RTT (both p<0.03), while stable ratios were detected in controls. Glx/Cr was elevated in RTT subjects younger than 10 years (p=0.024). Cho/Cr ratio was stable across the examined age range in both groups.
