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. Author manuscript; available in PMC: 2009 May 4.
Published in final edited form as: J Immunol. 2009 Mar 1;182(5):2583–2589. doi: 10.4049/jimmunol.0803247

Figure 1. FcRn is required for IgG transport to fetus.

Figure 1

Serum concentrations, determined by ELISA, of IgG (Panel A) and albumin (Panel B) were normalized to transferrin levels to minimize inter-animal variation. Each point represents the fetal serum concentration of an individual pre-term fetus plotted against its maternal serum concentration. Mean values with SD and the number of fetuses in each strain (Nf) and mothers (Nm) are shown. Panel A: The mean fetal IgG concentration was significantly lower in FcRn−/− fetuses (✕) compared with both FcRn+/+ (●) and FcRn+/− (∆) fetuses. Also, the IgG level in FcRn+/− fetuses was about half that of FcRn+/+ fetuses. Panel B: Albumin concentrations of FcRn−/− fetuses were also significantly lower than in both FcRn+/− and FcRn+/+ strains.