Table 1.
Animal | Dose | C max (ug/mL) | AUC (uM * min) | t 1/2 (h) | Clearance (mL/min/kg) |
---|---|---|---|---|---|
#1 (RQ 2633) | 4 mg/kg | 3.01 | 1182 | 1.47 | 3.85 |
#2 (RC 902) | 4 mg/kg | 2.70 | 997.8 | 1.18 | 5.40 |
Average | 2.84 | 1090 | 1.33 | 4.63 | |
#3 (RQ 2929) | 6 mg/kg | 5.80 | 1992 | 1.6 | 2.85 |
#4 (RQ 2937) | 6 mg/kg | 4.55 | 2039 | 1.9 | 2.52 |
Average | 5.18 | 2016 | 1.75 | 2.69 | |
Prior studies | |||||
Adults | 3.2 mg/kg (QD)* | 3.92 | 4867 | 2.6 | 2.49 |
3.2 mg/kg (QD)** | 3.75 | 5561 | 2.6 | 2.37 | |
Children | 3.2–4 mg/kg (QID)+ | 883 | 2.2 | 5.0 | |
3.2 mg/kg (QID)++ | 1070 | 1.98 | 3.92 |