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. Author manuscript; available in PMC: 2009 May 4.
Published in final edited form as: Exp Hematol. 2006 Feb;34(2):132–139. doi: 10.1016/j.exphem.2005.10.010

Table 1.

Pharmacokinetic data of single bolus dose of intravenous busulfan is rhesus macaques

Animal Dose C max (ug/mL) AUC (uM * min) t 1/2 (h) Clearance (mL/min/kg)
#1 (RQ 2633) 4 mg/kg 3.01 1182 1.47 3.85
#2 (RC 902) 4 mg/kg 2.70 997.8 1.18 5.40
Average 2.84 1090 1.33 4.63
#3 (RQ 2929) 6 mg/kg 5.80 1992 1.6 2.85
#4 (RQ 2937) 6 mg/kg 4.55 2039 1.9 2.52
Average 5.18 2016 1.75 2.69
Prior studies
 Adults 3.2 mg/kg (QD)* 3.92 4867 2.6 2.49
3.2 mg/kg (QD)** 3.75 5561 2.6 2.37
 Children 3.2–4 mg/kg (QID)+ 883 2.2 5.0
3.2 mg/kg (QID)++ 1070 1.98 3.92

These animals did not receive genetically modified cells.

*

3.2 mg/kg once daily for 4 days [28].

**

3.2 mg/kg once daily for 4 days [29].

+

0.8 to 1 mg/kg every 6 hours for 16 doses [26].

++

0.8 to 1 mg/kg every 6 hours for 12 doses [25].