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Influenza virus infection induces antiviral IgM without affecting serum levels of natural antiviral IgM. Sixteen allotype chimeras were infected with influenza virus and groups of eight mice were bled on alternating days as indicated. Serum levels of anti-influenza virus-specific IgMa (PerC donor-derived) and IgMb (host-derived) were determined by ELISA. ●, Mean levels; ■, data from individual mice. Bars = SD.
